Hypertension has relatively large morbidity and mortality rates throughout the world, including in Indonesia.The prevalence of hypertension tends to be greater in patients with a family history of hypertension.This is thought to be influenced by polymorphisms C in the methylenetetrahydrofolate reductase (MTHFR) gene.This study aims to determine the relationship between the polymorphism of C677T and the A1298C MTHFR gene as a risk factor for essential hypertension.An observational study with a case-control design was conducted involving 37 cases and 30 control people.
Data obtained by PCR-RFLP.Data analysis was performed using chi-square and odds ratio calculations.The most common genotype for C677T polymorphism is CC (94.6%) followed by CT and TT with 2.7% each (p = 0.
001) with OR of 0.099 (CI95% = 0.02-0.49).The most common genotype for the A1298C polymorphism is AC (45.
9%), followed by AA (35.1%) and CC (19%) (p = 0.001).The C allele is present in Platform Beds 24 subjects in the case group (64.8%) and in 7 subjects in the control group (23.
3%).The OR for the A1298C is 6.06 (CI 95% = 2.1-17.9).
The C677T polymorphism showed statistical significance but did not modify the risk factor of essential hypertension.Whereas the A1298C polymorphism is statistically significant and has a 6-fold risk factor for essential hypertension, polymorphism A1298C Methyltetrahydrofolate Reductase (MTHFR) gene is a risk factor of essential hypertension.